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Ultradeformable liposomes with terpenes for delivery of hydrophilic compound.

Journal of liposome research (2012-06-06)
Thirapit Subongkot, Sureewan Duangjit, Theerasak Rojanarata, Praneet Opanasopit, Tanasait Ngawhirunpat
ABSTRACT

Ultradeformable liposomes containing penetration enhancers were created to deliver NaFl. Vesicles were investigated for their particle size, zeta potential, NaFl entrapment efficiency (%EE), loading efficiency, and in vitro skin penetration. The vesicles obtained were spherical in shape, with a particle size of less than 100 nm and a negative surface charge (-6 to -11 mV). The %EE of NaFl loaded in vesicles ranged from 37 to 48%. Ultradeformable liposomes with monoterpenes (d-limonene, 1,8-cineole and geraniol) significantly improved NaFl penetration through the skin. Confocal laser scanning microscopy analysis confirmed skin-penetration results and was used to evaluate the behavior of hydrophilic compounds penetrating through the skin.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Eucalyptol, 99%
Sigma-Aldrich
Geraniol, 98%
Supelco
Eucalyptol, analytical standard
Sigma-Aldrich
Eucalyptol, natural, ≥99%, FCC, FG
Sigma-Aldrich
Geraniol, natural, ≥97%, FG
Sigma-Aldrich
Geraniol, ≥97%, FCC, FG
Supelco
1,8-Cineole, primary reference standard
Supelco
Geraniol, analytical standard
Sigma-Aldrich
cis-3,7-Dimethyl-2,6-octadien-1-ol, 97%
Sigma-Aldrich
cis-3,7-Dimethyl-2,6-octadien-1-ol, ≥97%, FCC, FG
Cineole, European Pharmacopoeia (EP) Reference Standard
Supelco
Eucalyptol, certified reference material, TraceCERT®