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Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs.

Chemical communications (Cambridge, England) (2012-07-17)
Vladimir B Arion, Anatolie Dobrov, Simone Göschl, Michael A Jakupec, Bernhard K Keppler, Peter Rapta
ABSTRACT

A modified paullone ligand bearing a TEMPO free-radical unit (HL) and its ruthenium(II) and osmium(II)-arene complexes [M(p-cymene)(HL)Cl]Cl·nH(2)O (M = Ru, Os) exhibit high antiproliferative activity in human cancer cell lines.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Osmium, powder, 99.9% trace metals basis