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Solubilisation capacity of Brij surfactants.

International journal of pharmaceutics (2012-07-31)
Maria E N P Ribeiro, Carolina L de Moura, Mariano G S Vieira, Nilce V Gramosa, Chiraphon Chaibundit, Marcos C de Mattos, David Attwood, Stephen G Yeates, S Keith Nixon, Nágila M P S Ricardo
ABSTRACT

The aim of this study was to investigate the potential of selected Brij non-ionic surfactants for enhancing the solubility of poorly water-soluble drugs. Griseofulvin was selected as a model drug candidate enabling comparisons to be made with the solubilisation capacities of other poly(ethylene oxide)-based copolymers. UV/Vis and (1)H NMR spectroscopies were used to quantify the enhancement of solubility of griseofulvin in 1 wt% aqueous micellar solutions of Brij 78 (C(18)H(37)E(20)), Brij 98 (C(18)H(35)E(20)) and Brij 700 (C(18)H(37)E(100)) (where E represents the OCH(2)CH(2) unit of the poly(ethylene oxide) chain) at 25, 37 and 40 °C. Solubilisation capacities (S(cp) expressed as mg griseofulvin per g Brij) were similar for Brij 78 and 98 (range 6-11 mg g(-1)) but lower for Brij 700 (3-4 mg g(-1)) as would be expected for the surfactant with the higher ethylene oxide content. The drug loading capacity of micelles of Brij 78 was higher than many di- and triblock copolymers with hydrophilic E-blocks specifically designed for enhancement of drug solubility.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Brij® S 100, average Mn ~4,670
Sigma-Aldrich
BRIJ® O20, average Mn ~1,150
Sigma-Aldrich
SP Brij® S2 MBAL, main component: diethylene glycol octadecyl ether
Sigma-Aldrich
Griseofulvin, from Penicillium griseofulvum, 97.0-102.0%
Sigma-Aldrich
Brij® S20
Sigma-Aldrich
Brij® 93, average Mn ~357
Sigma-Aldrich
Brij® S10, average Mn ~711
Sigma-Aldrich
Brij® O10
Sigma-Aldrich
ECO Brij® S100, average Mn ~4,670
Sigma-Aldrich
ECO Brij® S20
Sigma-Aldrich
ECO Brij® S10, average Mn ~711
Sigma-Aldrich
ECO BRIJ® O20, average Mn ~1,150
Sigma-Aldrich
ECO BRIJ® O10