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  • Propyl gallate plays a nephroprotective role in early stage of diabetic nephropathy associated with suppression of glomerular endothelial cell proliferation and angiogenesis.

Propyl gallate plays a nephroprotective role in early stage of diabetic nephropathy associated with suppression of glomerular endothelial cell proliferation and angiogenesis.

Experimental diabetes research (2012-09-19)
Shaojiang Tian, Junming Tang, Huihui Liu, Liping Wang, Jianming Shen, Junfeng Li, Yanjie Gan
ABSTRACT

There is growing evidence suggesting that glomerular endothelial cell proliferation and angiogenesis may be responsible for the pathophysiological events in the early stage of diabetic nephropathy. This study was designed to investigate the factors related to glomerular endothelial cell proliferation and glomerular angiogenesis and assess the effect of propyl gallate on preventing these disorders in diabetic rats. We found that glomerular hypertrophy, glomerular mesangial matrix expansion, and albuminuria were significantly increased in DN rats. CD31+ endothelial cells significantly increased in glomerulus of diabetic rats. Double immunofluorescence staining showed some structurally defective vasculus tubes in glomerulus. Real-time PCR and western blot demonstrated the glomerular eNOS expression remained at the same level, while remarkable decreased NO productions and suppressed eNOS activities were observed in diabetic rats. Treatment with propyl gallate improved glomerular pathological changes, reduced endothelial cell proliferation, decreased albuminuria, and restored eNOS activity, but did not alter eNOS expression. These data suggest that endothelial cell proliferation and immature angiogenesis may be the contributors to progression of DN. Propyl gallate is a potential novel therapeutic agent on prevention of diabetic nephropathy.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Propyl gallate, for microscopy, ≥98.0% (HPLC)
Sigma-Aldrich
Propyl gallate, antioxidant, ≥98.0% (HPLC)
Sigma-Aldrich
Propyl gallate, ≥98%, FCC
Sigma-Aldrich
Propyl gallate, powder
Supelco
Propyl gallate, Pharmaceutical Secondary Standard; Certified Reference Material