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A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells.

Angewandte Chemie (International ed. in English) (2012-11-06)
Jungwoon Lee, Yan Xia, Mi-Young Son, Guanghai Jin, Binna Seol, Min-Jeong Kim, Myung Jin Son, Misol Do, Minho Lee, Dongsup Kim, Kyeong Lee, Yee Sook Cho
ABSTRACT

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3-Indolepropionic acid, ReagentPlus®, 99%
Sigma-Aldrich
Indole-3-propionic acid, ≥99.0% (T)
Sigma-Aldrich
Indole-3-propionic acid, ≥97.0% (T)
Sigma-Aldrich
3-Indoleacrylic acid, BioReagent, ≥98% (HPLC)
Sigma-Aldrich
trans-3-Indoleacrylic acid, 98%
Sigma-Aldrich
3-Indoleacrylic acid, powder
Sigma-Aldrich
RSC133, ≥98% (HPLC)

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