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Skin regeneration after chemical burn under the effect of taxifolin-based preparations.

Bulletin of experimental biology and medicine (2013-01-19)
V S Shubina, Yu V Shatalin
ABSTRACT

We studied the effect of liposome preparation containing taxifolin oligomers and taxifolin conjugates with carbonyl compounds on skin regeneration after chemical burn. The preparations containing flavonoid conjugates intensified regeneration processes and reparation of hair follicles and sebaceous glands after chemical burn. The preparation based on taxifolin conjugate with acetaldehyde was most effective; its activity was comparable with that of the wound-healing preparation Olasol. Taxifolin conjugates with carbonyl compounds can be used for the creation of combined wound- and burn-healing preparations.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Acetaldehyde, ACS reagent, ≥99.5%
Supelco
Acetaldehyde, puriss. p.a., anhydrous, ≥99.5% (GC)
Supelco
Acetaldehyde, ReagentPlus®, ≥99.0% (GC)
Sigma-Aldrich
Acetaldehyde, natural, FG
Supelco
Acetaldehyde, PESTANAL®, analytical standard
Supelco
Taxifolin, analytical standard
Sigma-Aldrich
Acetaldehyde solution, 40 wt. % in H2O
Sigma-Aldrich
Acetaldehyde solution, natural, 50 wt. % ethanol, FG
Sigma-Aldrich
Acetaldehyde solution, 50 wt. % in ethanol
Sigma-Aldrich
Acetaldehyde, ≥99%, meets FCC analytical specification
Sigma-Aldrich
Acetaldehyde solution, 5 M in THF
Taxifolin, primary reference standard
Sigma-Aldrich
Acetaldehyde solution, 40 wt. % in isopropanol