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Efficient and regioselective ruthenium-catalyzed hydro-aminomethylation of olefins.

Journal of the American Chemical Society (2013-02-20)
Lipeng Wu, Ivana Fleischer, Ralf Jackstell, Matthias Beller
ABSTRACT

An efficient and regioselective ruthenium-catalyzed hydroaminomethlyation of olefins is reported. Key to success is the use of specific 2-phosphino-substituted imidazole ligands and triruthenium dodecacarbonyl as catalyst. Both industrially important aliphatic as well as various functionalized olefins react with primary and secondary amines to give the corresponding secondary and tertiary amines generally in high yields (up to 96%) and excellent regioselectivities (n/iso up to 99:1).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ruthenium, powder, 99.99% trace metals basis
Sigma-Aldrich
Ruthenium, powder, −200 mesh, 99.9% trace metals basis
Sigma-Aldrich
Ruthenium black
Sigma-Aldrich
Ruthenium, sponge, −100 mesh, 99.9% trace metals basis

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