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Ulcers caused by bullous morphea: successful therapy with N-acetylcysteine and topical wound care.

International journal of immunopathology and pharmacology (2013-03-27)
E Rosato, M L Veneziano, A Di Mario, I Molinaro, S Pisarri, F Salsano
ABSTRACT

Bullous morphea is an uncommon form of localized scleroderma. The pathogenesis is unknown and treatment of coexistent ulcers is difficult. The pathogenesis of bullae formation in morphea is multifactorial, but reactive oxygen species production appears to play a key role. We report a patient with bullous morphea with long-standing ulcers whom we successfully treated with N-acetylcysteine and topical wound care. N-acetylcysteine, an antioxidant sulfhydryl substance, promotes the healing of ulcers in patients with bullous morphea.

MATERIALS
Product Number
Brand
Product Description

Acetylcysteine, European Pharmacopoeia (EP) Reference Standard
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N-Acetyl-L-cysteine, Sigma Grade, ≥99% (TLC), powder
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N-Acetyl-L-cysteine, BioXtra, ≥99% (TLC)
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N-Acetyl-L-cysteine, BioReagent, suitable for cell culture
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N-Acetyl-L-cysteine, Pharmaceutical Secondary Standard; Certified Reference Material