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Chemical reactivity and mutagenicity of some dihalomethanes.

Chemico-biological interactions (1983-08-15)
S Osterman-Golkar, S Hussain, S Walles, B Anderstam, K Sigvardsson
ABSTRACT

Four dihalomethanes; dichloromethane, bromochloromethane, dibromomethane and diiodomethane, have been studied with respect to their reactivities towards nucleophilic compounds of different strengths in water solution and with respect to their toxicities and mutagenic effectiveness in bacterial test systems. The correlation between biological activity (toxicity and mutagenic effectiveness in Salmonella TA100) and reactivity towards strong nucleophiles indicates that reactions with nucleophilic groups of high reactivity in the biological material, possibly SH or amino groups in proteins, are involved in their mechanism of action.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Bromochloromethane, contains 100 ppm BHT as inhibitor, ≥99.5%
Supelco
Bromochloromethane, analytical standard
Supelco
Bromochloromethane solution, certified reference material, 2000 μg/mL in methanol