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Comparative effects of various lead salts on delayed hypersensitivity in mice.

Journal of applied toxicology : JAT (1984-10-01)
J Descotes, J C Evreux, A Laschi-Locquerie, P Tachon
ABSTRACT

Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell-mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Lead oxide, red powder, 1-2 μm, 99%
Sigma-Aldrich
Lead(II) carbonate, ACS reagent
Sigma-Aldrich
Lead(II,IV) oxide, ≥96%