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Relationship between metabolism and radioprotective activity of 2-phenylthiazolidine and its m-bromo derivative.

Journal of medicinal chemistry (1983-09-01)
J P Fernandez, Y Robbe, J P Chapat, J L Chanal, M Genin, H Sentenac-Roumanou, M Fatome
ABSTRACT

Molecular biotransformation of 2-phenylthiazolidine (1) and its m-bromo derivative (2) in the mouse is followed by autoradiographic studies and assessed by analysis of urinary metabolites. Cysteamine (4) is one of the metabolites of compounds 1 and 2. Radioprotective activity and efficacy over a period of time of 1, 2, and 4 correlate closely with distribution and metabolism.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3-Bromobenzaldehyde, 97%

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