Severe rhabdomyolysis after doxylamine overdose.

Postgraduate medicine (1993-06-01)
L F Soto, C H Miller, A J Ognibere
ABSTRACT

Clinicians should be aware of the complications of rhabdomyolysis in patients who ingest doxylamine succinate and other over-the-counter antihistamines. The easy availability of these substances increases the potential not only for intentional overdose by adults but also for inadvertent ingestion by children. Prompt intervention and careful assessment of renal function, urinary output, and serum creatine kinase levels may represent the difference between an uncomplicated course and acute renal failure.

MATERIALS
Product Number
Brand
Product Description

Supelco
Doxylamine succinate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
Doxylamine succinate salt