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The use of biomonitoring data in exposure and human health risk assessment: benzene case study.

Critical reviews in toxicology (2013-01-26)
Scott M Arnold, Juergen Angerer, Peter J Boogaard, Michael F Hughes, Raegan B O'Lone, Steven H Robison, A Robert Schnatter
ABSTRACT

Abstract A framework of "Common Criteria" (i.e. a series of questions) has been developed to inform the use and evaluation of biomonitoring data in the context of human exposure and risk assessment. The data-rich chemical benzene was selected for use in a case study to assess whether refinement of the Common Criteria framework was necessary, and to gain additional perspective on approaches for integrating biomonitoring data into a risk-based context. The available data for benzene satisfied most of the Common Criteria and allowed for a risk-based evaluation of the benzene biomonitoring data. In general, biomarker (blood benzene, urinary benzene and urinary S-phenylmercapturic acid) central tendency (i.e. mean, median and geometric mean) concentrations for non-smokers are at or below the predicted blood or urine concentrations that would correspond to exposure at the US Environmental Protection Agency reference concentration (30 µg/m(3)), but greater than blood or urine concentrations relating to the air concentration at the 1 × 10(-5) excess cancer risk (2.9 µg/m(3)). Smokers clearly have higher levels of benzene exposure, and biomarker levels of benzene for non-smokers are generally consistent with ambient air monitoring results. While some biomarkers of benzene are specific indicators of exposure, the interpretation of benzene biomonitoring levels in a health-risk context are complicated by issues associated with short half-lives and gaps in knowledge regarding the relationship between the biomarkers and subsequent toxic effects.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Benzene, anhydrous, 99.8%
Sigma-Aldrich
Benzene, suitable for HPLC, ≥99.9%
Supelco
Benzene, analytical standard
Sigma-Aldrich
Benzene, ACS reagent, ≥99.0%
Supelco
Benzene, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Benzene solution, certified reference material, TraceCERT®, 200 μg/mL in methanol
Sigma-Aldrich
Benzene, puriss. p.a., reag. Ph. Eur., ≥99.7%

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