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Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats.

General pharmacology (1999-07-31)
C A Tagliati, E Kimura, M S Nothenberg, S R Santos, S Oga
ABSTRACT

Complexation of piroxicam with zinc extends its absorption time in rats. The time of peak concentration value for complexed piroxicam was 5.27 hr compared to only 2.56 hr for the uncomplexed agent. Piroxicam and zinc-piroxicam show similar inhibitory effects on carrageenin-induced paw edema. Zinc-piroxicam is less irritating than piroxicam on the gastric mucosa.