MilliporeSigma
  • Home
  • Search Results
  • Treatment of adult systemic mastocytosis with interferon-alpha: results of a multicentre phase II trial on 20 patients.

Treatment of adult systemic mastocytosis with interferon-alpha: results of a multicentre phase II trial on 20 patients.

British journal of haematology (2002-12-11)
Philippe Casassus, Nadine Caillat-Vigneron, Antoine Martin, Jeanne Simon, Valérie Gallais, Patrice Beaudry, Virginie Eclache, Liliane Laroche, Pierre Lortholary, Martine Raphaël, Loïc Guillevin, Olivier Lortholary
ABSTRACT

Systemic mastocytosis (SM) is characterized by proliferation of mast cells in various organs, which may release a wide variety of mediators, thereby explaining the broad clinical spectrum of disease manifestations. The potentially life-threatening systemic symptoms and tumoral proliferation are poorly controlled despite the use of several cytotoxic chemotherapies and/or symptomatic treatments. Twenty consecutive adult SM patients with histologically confirmed bone marrow (BM) involvement received interferon-alpha subcutaneously (1-5 million units/m2/d, with progressive dose intensification over the first month of treatment) and were evaluated after 6 months of therapy. Seven of them had previously received symptomatic treatments, including steroids, which were ineffective. Among the 13 patients treated for at least 6 months, seven partial and six minor responses, mainly concerning vascular congestion and skin lesions, were obtained, while BM infiltration remained unchanged in 12 patients. The significant reduction of mast-cell mediator levels after 6 months of treatment was not predictive of clinical remission. The rate of depression was unexpectedly high (seven patients; 35%). Two patients died soon after starting therapy (one myocardial infarction, one septic shock). Six months of interferon-alpha may relieve vascular congestion in adults with SM, probably by inhibiting mast-cell degranulation.