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Hexamethylenebisacetamide selectively inhibits the proliferation of human and rat vascular smooth-muscle cells.

The Biochemical journal (1992-04-15)
D J Grainger, T R Hesketh, P L Weissberg, J C Metcalfe
ABSTRACT

Hexamethylenebisacetamide (HMBA) selectively and reversibly inhibited proliferation of human and rat vascular smooth-muscle cells (VSMCs) compared with endothelial cells, fibroblasts or lymphocytes. Half-maximal inhibition of VSMC proliferation occurred at 2-5 mM-HMBA, and at 30- greater than 50 mM for other cell types. HMBA also prevented de-differentiation, defined by the loss of smooth-muscle-specific myosin heavy chain, of primary rat VSMCs and caused partial re-differentiation of subcultured cells. Other inhibitors of ADP-ribosyltransferase were also selective inhibitors of VSMC proliferation.

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Sigma-Aldrich
4-Hydroxyquinazoline, 98%