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Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains.

Bioorganic & medicinal chemistry letters (2005-03-23)
Sheng-Li Cao, Yu-Ping Feng, Yu-Yang Jiang, Shi-Ying Liu, Guo-Yu Ding, Run-Tao Li
ABSTRACT

A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC(50) value of 0.5 microM.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Hydroxyquinazoline, 98%