Antiviral flavonoids from Mosla scabra.

Fitoterapia (2009-12-17)
Qiaofeng Wu, Chenhuan Yu, Yunliang Yan, Jing Chen, Chunchun Zhang, Xinxin Wen
ABSTRACT

An ethanolic extract and ethyl acetate fraction (EFMS) prepared from Mosla scabra showed potential inhibition against influenza viruses. The compounds isolated from EFMS were elucidated to be ursolic acid (1), 5-hydroxy-6,7-dimethoxyflavone (2), 5-hydroxy-7,8-dimethoxyflavone (3), apigenin (4) and acacetin (5) based on their spectral analysis. Compounds 2, 3, 4 and 5 showed significant anti-influenza viruses activities. Compared with ribavirin, EFMS appeared to have similar efficacy against influenza viruses, was considered to be less toxic and may warrant further evaluation as a possible agent for the treatment of influenza.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Acacetin, ≥97.0% (HPLC)