MilliporeSigma

Allergic contact dermatitis of the vulva.

Dermatitis : contact, atopic, occupational, drug (2013-03-12)
Susan M O'Gorman, Rochelle R Torgerson
ABSTRACT

Allergic contact dermatitis (ACD) of the vulva arises as a primary condition or develops secondary to topical agents. We aimed to describe the incidence of ACD in patients presenting with vulvar symptoms and to identify the allergens of most importance. Using a database of the patch testing results from 3 geographically distinct sites, we identified patients tested to a gynecologic series between 2003 and 2010. Patients had patch testing to the standard European battery and a gynecologic series. Patch testing was in line with accepted universal methods: application on day 1, allergen removal and initial reading on day 3, and final reading on day 5. Ninety patients were included. Thirty-five (39%) had a relevant positive result. The 5 allergens with the highest number of cases with a relevant reaction were natural fragrance mix 2%, balsam of Peru, benzocaine 5%, fragrance mix 8%, and quaternium 15 1%. The most common gynecologic series allergen to cause a relevant reaction was terconazole. Allergic contact dermatitis is a frequent finding in patients presenting with vulvar symptoms. We identified a relevant positive result to patch testing in 39%. We found fragrances, medicaments, and preservatives to be of most relevance.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Hexamethylenetetramine, ReagentPlus®, 99%
Sigma-Aldrich
Hexamethylenetetramine, ACS reagent, ≥99.0%
Sigma-Aldrich
Ethyl 4-aminobenzoate, 98%
Sigma-Aldrich
Hexamethylenetetramine, meets analytical specification of Ph. Eur., BP, 99-100.5% (calc. to the dried substance)
Sigma-Aldrich
Hexamethylenetetramine, puriss. p.a., reag. Ph. Eur., ≥99.5% (calc. to the dried substance)
Methenamine, European Pharmacopoeia (EP) Reference Standard
Supelco
Hexamethylenetetramine
Sigma-Aldrich
Benzocaine, ≥99% (HPLC)
Sigma-Aldrich
Peru balsam
Supelco
Benzocaine, Pharmaceutical Secondary Standard; Certified Reference Material