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Indoles synthesized from amines via copper catalysis.

Organic letters (2013-03-15)
Ronald Besandre, Miguel Jaimes, Jeremy A May
ABSTRACT

N-substituted indoles are synthesized from primary amines through a tandem reaction sequence. Initial condensation of the amine with an α-(o-haloaryl)ketone or aldehyde is followed by intramolecular aryl amination catalyzed by CuI. A variety of anilines and alkyl amines, including those with significant steric demands, are converted to indoles in high yields and with varying indole substitution.

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