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  • Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery.

Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery.

Carbohydrate polymers (2013-04-03)
Santanu Kaity, Jinu Isaac, Animesh Ghosh
PMID23544563
ABSTRACT

A novel interpenetrating polymer network (IPN) microspheres of locust bean gum (LBG) and poly (vinyl alcohol) (PVA) was developed for oral controlled release of buflomedil hydrochloride (BH) by emulsion crosslinking method using glutaraldehyde as crosslinker. The effects of gum-polymer ratio, concentration of crosslinker and internal phase viscosity were evaluated thoroughly. Drug entrapment efficiency, particle size distribution, swelling property and in vitro release characteristics with kinetic modelling of microspheres were evaluated. The microspheres were characterised by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), solid state C(13) NMR, X-ray diffraction study (XRD) and differential scanning colorimetry (DSC). The microspheres showed control release property without showing any incompatibility in IPN device. Hence, IPN microspheres of LBG and PVA can be used as a potential carrier for controlled oral delivery of highly water soluble drugs like BH.

MATERIALS
Product Number
Brand
Product Description
P1763
Sigma-Aldrich
Poly(vinyl alcohol), Fully hydrolyzed
P8136
Sigma-Aldrich
Poly(vinyl alcohol), 87-90% hydrolyzed, average mol wt 30,000-70,000
G6403
Sigma-Aldrich
Glutaraldehyde solution, 50% in H2O, suitable for photographic applications
G5882
Sigma-Aldrich
Glutaraldehyde solution, Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative
G7651
Sigma-Aldrich
Glutaraldehyde solution, Grade I, 50% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
G6257
Sigma-Aldrich
Glutaraldehyde solution, Grade II, 25% in H2O
G7776
Sigma-Aldrich
Glutaraldehyde solution, Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
10853
Sigma-Aldrich
Mowiol® 6-98, Mw ~47,000
10852
Sigma-Aldrich
Mowiol® 10-98, Mw ~61,000
11773
Sigma-Aldrich
Mowiol® 20-98, Mw ~125,000
348406
Sigma-Aldrich
Poly(vinyl alcohol), average Mw 13,000-23,000, 98% hydrolyzed
363073
Sigma-Aldrich
Poly(vinyl alcohol), average Mw 31,000-50,000, 87-89% hydrolyzed
363065
Sigma-Aldrich
Poly(vinyl alcohol), Mw 146,000-186,000, 99+% hydrolyzed
340855
Sigma-Aldrich
Glutaraldehyde solution, 50 wt. % in H2O
360627
Sigma-Aldrich
Poly(vinyl alcohol), Mw 9,000-10,000, 80% hydrolyzed
363170
Sigma-Aldrich
Poly(vinyl alcohol), Mw 13,000-23,000, 87-89% hydrolyzed
363146
Sigma-Aldrich
Poly(vinyl alcohol), Mw 85,000-124,000, 99+% hydrolyzed
341584
Sigma-Aldrich
Poly(vinyl alcohol), Mw 89,000-98,000, 99+% hydrolyzed
363138
Sigma-Aldrich
Poly(vinyl alcohol), Mw 31,000-50,000, 98-99% hydrolyzed
363081
Sigma-Aldrich
Poly(vinyl alcohol), average Mw 85,000-124,000, 87-89% hydrolyzed
363103
Sigma-Aldrich
Poly(vinyl alcohol), average Mw 146,000-186,000, 87-89% hydrolyzed
81381
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Mowiol® 4-88, Mw ~31,000
81383
Sigma-Aldrich
Mowiol® 8-88, Mw ~67,000
81382
Sigma-Aldrich
Mowiol® 4-98, Mw ~27,000
G7526
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Glutaraldehyde solution, Grade I, 8% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
563900
Sigma-Aldrich
Poly(vinyl alcohol), average Mw 130,000, 99+% hydrolyzed
10851
Sigma-Aldrich
Mowiol® 56-98, Mw ~195,000
10849
Sigma-Aldrich
Mowiol® 28-99, Mw ~145,000
324590
Sigma-Aldrich
Mowiol® 40-88, average Mw ~205,000 g/mol
81365
Sigma-Aldrich
Mowiol® 18-88, Mw ~130,000