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Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery.

Carbohydrate polymers (2013-04-03)
Santanu Kaity, Jinu Isaac, Animesh Ghosh
ABSTRACT

A novel interpenetrating polymer network (IPN) microspheres of locust bean gum (LBG) and poly (vinyl alcohol) (PVA) was developed for oral controlled release of buflomedil hydrochloride (BH) by emulsion crosslinking method using glutaraldehyde as crosslinker. The effects of gum-polymer ratio, concentration of crosslinker and internal phase viscosity were evaluated thoroughly. Drug entrapment efficiency, particle size distribution, swelling property and in vitro release characteristics with kinetic modelling of microspheres were evaluated. The microspheres were characterised by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), solid state C(13) NMR, X-ray diffraction study (XRD) and differential scanning colorimetry (DSC). The microspheres showed control release property without showing any incompatibility in IPN device. Hence, IPN microspheres of LBG and PVA can be used as a potential carrier for controlled oral delivery of highly water soluble drugs like BH.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Glutaraldehyde solution, Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative
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Mowiol® 4-88, Mw ~31,000
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Poly(vinyl alcohol), Mw 146,000-186,000, 99+% hydrolyzed
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Glutaraldehyde solution, Grade I, 50% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
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Poly(vinyl alcohol), Mw 85,000-124,000, 99+% hydrolyzed
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Glutaraldehyde solution, Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
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Poly(vinyl alcohol), Mw 31,000-50,000, 98-99% hydrolyzed
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Poly(vinyl alcohol), average Mw 13,000-23,000, 98% hydrolyzed
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Poly(vinyl alcohol), average Mw 85,000-124,000, 87-89% hydrolyzed
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Poly(vinyl alcohol), Fully hydrolyzed
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Poly(vinyl alcohol), average Mw 31,000-50,000, 87-89% hydrolyzed
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Glutaraldehyde solution, Grade I, 8% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
Sigma-Aldrich
Mowiol® 10-98, Mw ~61,000
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Mowiol® 18-88, Mw ~130,000
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Poly(vinyl alcohol), average Mw 146,000-186,000, 87-89% hydrolyzed
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Poly(vinyl alcohol), average Mw 130,000, 99+% hydrolyzed
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Mowiol® 40-88, average Mw ~205,000 g/mol
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Mowiol® 4-98, Mw ~27,000
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Mowiol® 8-88, Mw ~67,000
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Mowiol® 28-99, Mw ~145,000
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Glutaraldehyde solution, 50% in H2O, suitable for photographic applications
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