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Preparation and physicochemical properties of surfactant-free emulsions using electrolytic-reduction ion water containing lithium magnesium sodium silicate.

Drug discoveries & therapeutics (2013-05-30)
Masahiro Okajima, Yuko Wada, Takashi Hosoya, Fumio Hino, Yoshiyasu Kitahara, Ken-ichi Shimokawa, Fumiyoshi Ishii
ABSTRACT

Surfactant-free emulsions by adding jojoba oil, squalane, olive oil, or glyceryl trioctanoate (medium chain fatty acid triglycerides, MCT) to electrolytic-reduction ion water containing lithium magnesium sodium silicate (GE-100) were prepared, and their physiochemical properties (thixotropy, zeta potential, and mean particle diameter) were evaluated. At an oil concentration of 10%, the zeta potential was ‒22.3 ‒ ‒26.8 mV, showing no marked differences among the emulsions of various types of oil, but the mean particle diameters in the olive oil emulsion (327 nm) and MCT emulsion (295 nm) were smaller than those in the other oil emulsions (452-471 nm). In addition, measurement of the hysteresis loop area of each type of emulsion revealed extremely high thixotropy of the emulsion containing MCT at a low concentration and the olive emulsion. Based on these results, since surfactants and antiseptic agents markedly damage sensitive skin tissue such as that with atopic dermatitis, surfactant- and antiseptic-free emulsions are expected to be new bases for drugs for external use.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Jojoba oil from Simmondsia chinensis, tested according to DAC
Sigma-Aldrich
Olive oil, tested according to Ph. Eur.
Sigma-Aldrich
Sodium metasilicate pentahydrate, ≥95.0% (T)
Sigma-Aldrich
Jojoba oil, Certified organic (NOP)
Supelco
Olive oil, analytical standard
Sigma-Aldrich
Olive oil, highly refined, low acidity
Sigma-Aldrich
Glyceryl trioctanoate, ≥99%
Sigma-Aldrich
Lithium, ribbon, thickness × W 0.75 mm × 45 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, ribbon, thickness × W 0.38 mm × 23 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, ribbon, thickness × W 1.5 mm × 100 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, wire (in mineral oil), diam. 3.2 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, ribbon, thickness × W 0.75 mm × 19 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, granular, 4-10 mesh particle size, high sodium, 99% (metals basis)
Sigma-Aldrich
Lithium, rod, diam. 12.7 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, wire, diam. 3.2 mm, in mineral oil, ≥98%
Sigma-Aldrich
Lithium, granular, 99% trace metals basis