Comparative Hemodynamic Activity of Glyceryl 2-Nitrate and Glyceryl Trinitrate in Various Species and Pharmacokinetics of Glyceryl 2-Nitrate in Dog A single dose of glyceryl 2-nitrate (G-2-N) had practically identical hypotensive and cardiovascular activity when administered intravenously or enterally to the anaesthetized rabbit, cat or dog. In all three species the hypotensive and also cardiovascular activity of G-2-N lasted much longer than that of glyceryl trinitrate (GTN, Nitro Mack). In the rabbit, cat and dog enterally active doses of GTN were 500-1000 times greater than parenterally active doses. In all species enterally administered GTN was about 8 times more active than enterally administered G-2-N. G-2-N is 100% bioavailable in the conscious dog.
Research. Development. Production.
We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.