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Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry.

Molecular diversity (1997-01-01)
J C Wijkmans, A J Culshaw, A D Baxter
ABSTRACT

4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenols to yield, after cleavage, the corresponding biaryl ethers in excellent purity. In a similar fashion, biaryl thioethers could be obtained. Further elaboration of immobilized biaryl ethers demonstrates the potential for combinatorial library generation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Fluoro-3-nitrobenzoic acid, 98%

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