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Bentiromide test using liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites for diagnosing pancreatic insufficiency in childhood.

The Journal of pediatrics (1992-09-01)
P R Durie, L Y Yung-Jato, S J Soldin, Z Verjee, L Ellis
ABSTRACT

We assessed the diagnostic capability of the bentiromide test using a high-pressure liquid-chromatography method to analyze p-aminobenzoic acid and its metabolites in plasma as an indirect measure of exocrine pancreatic function. Mean total amine concentration in pancreatic-insufficient subjects was significantly lower than in control subjects. There were 3 of 15 false-negative results and no false-positive results. We conclude that this chromatographic method is an effective means of analyzing p-aminobenzoic acid and its metabolites after ingestion of bentiromide.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Aminobenzoic acid, ReagentPlus®, ≥99%
Sigma-Aldrich
4-Aminobenzoic acid, ReagentPlus®, 99%
Supelco
4-Aminobenzoic acid, analytical standard
Sigma-Aldrich
4-Aminobenzoic acid, purified by sublimation, ≥99%