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Formation and characterization of stable human serum albumin-tris-malonic acid [C60]fullerene complex.

Bioconjugate chemistry (2005-09-22)
Bogdan Belgorodsky, Ludmila Fadeev, Varda Ittah, Hadar Benyamini, Stanislav Zelner, Dan Huppert, Alexander B Kotlyar, Michael Gozin
ABSTRACT

The preparation and characterization of the stable human serum albumin (HSA)-C3 isomer of tris-malonic acid [C60]fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein-fullerene complex with a native protein has never been observed. This study may provide valuable answers to the growing concern regarding the effects of carbonaceous nanomaterials on human health on one hand and, on the other, may lead to the development of novel antioxidant therapeutic agents, radiopharmaceuticals, and components for bioelectronic devices.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Malonic acid, ReagentPlus®, 99%
Supelco
Malonic acid, certified reference material, TraceCERT®