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Separation of two conjugates of clofibric acid (CPIB) found in the urine of subjects taking clofibrate.

Clinical and experimental pharmacology & physiology (1978-03-01)
E M Faed, E G McQueen
PMID648038
ABSTRACT

1. Two main conjugates of CPIB (2-[chlorophenoxy]-2-methylpropionic acid) are present in the urine of subjects taking clofibrate. The metabolites can be separated by thin-layer chromatography (TLC). 2. Both conjugates are hydrolysed by dilute alkali, but only one is hydrolysed by the enzyme beta-glucuronidase. In eighty-five urine specimens this conjugate accounted for an average of 54.5% (range 25-70%) of the total CPIB, while 2.6-12.45% (mean 5.1%) was present as free CPIB.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Isobutyric acid, 99%
Sigma-Aldrich
Isobutyric acid, puriss. p.a., ≥99.5%
Sigma-Aldrich
Isobutyric acid, ≥99%, FCC, FG
Supelco
Isobutyric acid, analytical standard
Sigma-Aldrich
Isobutyric acid, natural, ≥99%, FCC, FG