MilliporeSigma
  • Home
  • Search Results
  • 1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.

1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.

Journal of neurochemistry (1995-12-01)
Y Kotake, Y Tasaki, Y Makino, S Ohta, M Hirobe
ABSTRACT

1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography-selected ion-monitoring method. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls with other neurological diseases, the mean value being three times higher (parkinsonians: 1.17 +/- 0.35 ng/ml of CSF, n = 18; vs. controls: 0.40 +/- 0.10 ng/ml of CSF, n = 11; mean +/- SEM, not significantly different). The pole test, a toxicological examination to evaluate behavior abnormalities related to Parkinson's disease, was used to examine the pharmacological effect of 1BnTIQ in mice. Repeated administration of 1BnTIQ induced behavior abnormalities, which pretreatment with 1-methyl-1,2,3,4-tetrahydroisoquinoline could prevent. We suggest that 1BnTIQ may be related to the idiopathic Parkinson's disease.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Aluminum, sputtering target, diam. × thickness 3.00 in. × 0.125 in., 99.9995% trace metals basis
Sigma-Aldrich
Chromium, sputtering target, diam. × thickness 3.00 in. × 0.125 in., 99.95% trace metals basis
Sigma-Aldrich
Zinc, sputtering target, diam. × thickness 3.00 in. × 0.125 in., 99.995% trace metals basis
Sigma-Aldrich
Zirconium, powder, in water, -325 mesh, 99.5% trace metals basis (excluding Hf)
Sigma-Aldrich
Zinc, shot, 99.9999%
Supelco
L-Cystine, certified reference material, TraceCERT®
Supelco
Copper (impurities), manufactured by MBH Analytical Ltd (39X 17868)
Supelco
Tin (impurities), manufactured by MBH Analytical Ltd (71X SR0)
Sigma-Aldrich
Aluminum, foil, thickness 8 μm, 99% trace metals basis
Sigma-Aldrich
Magnesium, wire, 127 μm diameter, 99.9% trace metals basis
Sigma-Aldrich
Magnesium, in a Sure/Seal bottle, turnings, 37.5 mmol
Sigma-Aldrich
Magnesium, in a Sure/Seal bottle, turnings, anhydrous tetrahydrofuran 37.5 mmol
Sigma-Aldrich
Tin, powder, -100 mesh, 99.99% trace metals basis
Sigma-Aldrich
L-Cystine, produced by Wacker Chemie AG, Burghausen, Germany, ≥98.5%
Sigma-Aldrich
Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis
Sigma-Aldrich
Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%
Sigma-Aldrich
L-Cystine, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
Tungsten, powder (monocrystalline), 0.6-1 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Cobalt, foil, thickness 0.25 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Cobalt, wire, diam. 1.0 mm, 99.995% trace metals basis
Sigma-Aldrich
Cobalt, rod, diam. 5.0 mm, 99.998% trace metals basis
Sigma-Aldrich
Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis
Sigma-Aldrich
Cobalt, powder, <150 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Magnesium, ReagentPlus®, powder, −50 mesh, ≥99%
Sigma-Aldrich
Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis
Sigma-Aldrich
Molybdenum, powder, <150 μm, 99.99% trace metals basis
Sigma-Aldrich
Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis
Sigma-Aldrich
Molybdenum, powder, 1-5 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Titanium, wire, diam. 0.25 mm, 99.7% trace metals basis
Sigma-Aldrich
Zirconium, rod, diam. 6.35 mm, ≥99% trace metals basis