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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

Science (New York, N.Y.) (1987-02-20)
R E Tanzi, J F Gusella, P C Watkins, G A Bruns, P St George-Hyslop, M L Van Keuren, D Patterson, S Pagan, D M Kurnit, R L Neve
ABSTRACT

The amyloid beta protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the beta protein suggests that it derives from a larger protein expressed in a variety of tissues. Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the beta protein maps to chromosome 21. Regional localization of this gene by both physical and genetic mapping places it in the vicinity of the genetic defect causing the inherited form of Alzheimer's disease.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
Sigma-Aldrich
Anti-Amyloid Precursor Protein, N-Terminal antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
Sigma-Aldrich
Anti-phospho-APP (pThr668) antibody produced in rabbit, affinity isolated antibody, aqueous glycerol solution, 10 blots
Sigma-Aldrich
Anti-Amyloid Precursor Protein, KPI Domain antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

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