Four new members expand the interleukin-1 superfamily.

The Journal of biological chemistry (2000-01-08)
D E Smith, B R Renshaw, R R Ketchem, M Kubin, K E Garka, J E Sims
ABSTRACT

We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-IL-36A antibody produced in rabbit, affinity isolated antibody
Sigma-Aldrich
Anti-IL-36B antibody produced in rabbit, affinity isolated antibody
Sigma-Aldrich
Anti-IL-36G antibody produced in rabbit, affinity isolated antibody

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.