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  • IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.

IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.

Blood (2012-09-13)
Solenne Vigne, Gaby Palmer, Praxedis Martin, Céline Lamacchia, Deborah Strebel, Emiliana Rodriguez, Maria L Olleros, Dominique Vesin, Irene Garcia, Francesca Ronchi, Federica Sallusto, John E Sims, Cem Gabay
ABSTRACT

The interleukin-1 (IL-1) superfamily of cytokines comprises a set of pivotal mediators of inflammation. Among them, the action of IL-36 cytokines in immune responses has remained elusive. In a recent study, we demonstrated a direct effect of IL-36 on immune cells. Here we show that, among T cells, the IL-36 receptor is predominantly expressed on naive CD4(+) T cells and that IL-36 cytokines act directly on naive T cells by enhancing both cell proliferation and IL-2 secretion. IL-36β acts in synergy with IL-12 to promote Th1 polarization and IL-36 signaling is also involved in mediating Th1 immune responses to Bacillus Calmette-Guerin infection in vivo. Our findings point toward a critical function of IL-36 in the priming of Th1 cell responses in vitro, and in adaptive immunity in a model of mycobacterial infection in vivo.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-IL-36A antibody produced in rabbit, affinity isolated antibody
Sigma-Aldrich
Anti-IL-36B antibody produced in rabbit, affinity isolated antibody