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KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.

Nature genetics (2010-08-03)
Dewang Zhou, Kaimao Liu, Chiao-Wang Sun, Kevin M Pawlik, Tim M Townes
ABSTRACT

We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human gamma-globin/beta-globin expression ratios. These results suggest that KLF1 controls globin gene switching by directly activating beta-globin and indirectly repressing gamma-globin gene expression. Controlled knockdown of KLF1 in adult erythroid progenitors may provide a method to activate fetal hemoglobin expression in individuals with beta-thalassemia or sickle cell disease.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
Anti-KLF1 antibody produced in rabbit, affinity isolated antibody