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Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry.

Biomedical chromatography : BMC (2010-11-09)
Tomofumi Santa
ABSTRACT

Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and enhances the mass spectrometric ionization efficiency and MS/MS detectability. In this review, an overview of the derivatization reagents which have been applied to LC/ESI-MS/MS is presented, focusing on the applications to low molecular weight compounds.

MATERIALS
Product Number
Brand
Product Description

Supelco
Dansyl chloride, for HPLC derivatization, LiChropur, ≥99.0% (HPLC)
Supelco
Dansylhydrazine, for LC-MS derivatization, LiChropur, ≥95% (HPLC)