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Successful treatment of early myoclonic encephalopathy using lidocaine and carbamazepine.

Epileptic disorders : international epilepsy journal with videotape (2013-07-28)
Kousuke Nakano, Katsuhiro Kobayashi, Satoshi Maniwa, Nobuyuki Kodani, Yoko Ohtsuka
ABSTRACT

We report two female infants with early myoclonic encephalopathy (EME) whose intractable focal seizures were suppressed with lidocaine and carbamazepine (CBZ). Although EME is a form of early-onset epileptic encephalopathy characterised by myoclonus and focal seizures that are highly resistant to treatment, lidocaine and CBZ may prove effective in treating this disorder. Future studies should be performed in order to determine whether there are common specific mechanisms of seizure generation related to the sodium channel in these patients.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Carbamazepine, powder
Sigma-Aldrich
Carbamazepine, meets USP testing specifications
Supelco
Carbamazepine, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Carbamazepine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®