MilliporeSigma
  • Home
  • Search Results
  • Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner.

Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner.

Biochemical and biophysical research communications (2013-10-10)
Karamkolly R Rekha, Govindasamy P Selvakumar, Karunanithi Santha, Ramu Inmozhi Sivakamasundari
ABSTRACT

Parkinson's disease (PD) is characterized by progressive loss of dopamine (DA) neurons in the nigrostriatal system and by the presence of Lewy bodies (LB), proteinaceous inclusions mainly composed of filamentous α-synuclein (α-Syn) aggregates. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was adopted to generate PD models in C57BL/6 mice. In the present study, we investigated the effect of geraniol (GE) against α-Syn aggregation on MPTP induced mouse model of PD in dose dependant manner. When pretreatment of GE improved neuromuscular impairment, TH expressions and decreases α-Syn expressions in MPTP intoxicated PD mice by dose dependent manner. In addition, we confirmed that sub-chronic administration of MPTP in mice leads to permanent neuromuscular deficits and depletion of dopamine and its metabolites. Our results suggest that GE is beneficial for the treatment of PD associated with neuromuscular disability and LB aggregation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3,4-Dihydroxyphenylacetic acid, 98%
Sigma-Aldrich
Geraniol, natural, ≥97%, FG
Sigma-Aldrich
Geraniol, 98%
Sigma-Aldrich
Geraniol, ≥97%, FCC, FG
Supelco
Geraniol, analytical standard
Sigma-Aldrich
Monoamine Oxidase B human, recombinant, expressed in baculovirus infected BTI insect cells
Sigma-Aldrich
cis-3,7-Dimethyl-2,6-octadien-1-ol, 97%
Sigma-Aldrich
cis-3,7-Dimethyl-2,6-octadien-1-ol, ≥97%, FCC, FG
Sigma-Aldrich
Monoamine Oxidase A human, recombinant, expressed in baculovirus infected BTI insect cells