Anti-inflammatory activity of lipoic acid in mice peritonitis model.

Acta poloniae pharmaceutica (2013-10-24)
Małgorzata Zygmunt, Magdalena Dudek, Anna Bilska-Wilkosz, Marek Bednarski, Szczepan Mogilski, Joanna Knutelska, Jacek Sapa
ABSTRACT

This work aimed to investigate the effect of lipoic acid (LA) on sulfane sulfur (S*) level, infiltration of neutrophils and vascular permeability in a model of zymosan-induced peritonitis. The study showed that lipoic acid increased the sulfane sulfur level. Also, it decreased count of neutrophils and inhibition of intensity of early vascular permeability compared to the control group. These studies indicated that LA exhibits antiinflammatory activity. LA serves as a sulfane sulfur acceptor and releases sulfane sulfur in the form of hydrogen sulfide (H2S), which is probably responsible for its anti-inflammatory activity.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Indomethacin, 98.5-100.5% (in accordance with EP)
Supelco
Indomethacin, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Indomethacin, meets USP testing specifications
Indomethacin, European Pharmacopoeia (EP) Reference Standard