The role of iron and reactive oxygen species in cell death.

Nature chemical biology (2013-12-19)
Scott J Dixon, Brent R Stockwell
ABSTRACT

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are increasingly recognized as important initiators and mediators of cell death in a variety of organisms and pathological situations. Here, we review recent discoveries regarding the mechanism by which iron and ROS participate in cell death. We describe the different roles of iron in triggering cell death, targets of iron-dependent ROS that mediate cell death and a new form of iron-dependent cell death termed ferroptosis. Recent advances in understanding the role of iron and ROS in cell death offer unexpected surprises and suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Iron, ≥99%, reduced, powder (fine)
Sigma-Aldrich
Carbonyl iron, ≥97% Fe basis
Sigma-Aldrich
Iron, powder, −325 mesh, 97%
Sigma-Aldrich
Iron, powder, <10 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Iron, nanopowder, 35-45 nm particle size, 99.5% trace metals basis
Sigma-Aldrich
Iron, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)
Sigma-Aldrich
Iron, chips, 99.98% trace metals basis
Sigma-Aldrich
Iron, granular, 10-40 mesh, >99.99% trace metals basis
Sigma-Aldrich
Iron, foil, thickness 0.1 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Iron, flakes, ≥99.99% trace metals basis
Sigma-Aldrich
Iron, foil, thickness 0.25 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Iron, wire, diam. 1.0 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Iron, carbon coated magnetic, nanopowder, 25 nm avg. part. size, 99.5% trace metals basis
Iron, foil, 300x300mm, thickness 0.1mm, hard, 99.5%
Sigma-Aldrich
Iron, wire, diam. 1.0 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Iron, rod, diam. 6.3 mm, 99.98% trace metals basis
Iron, IRMM®, certified reference material, 0.5 mm wire
Iron, foil, 25x25mm, thickness 1.0mm, as rolled, 99.5%
Iron, foil, 100x100mm, thickness 1.0mm, as rolled, 99.99+%
Iron, foil, 100x100mm, thickness 0.25mm, hard, 99.5%
Iron, foil, 25x25mm, thickness 2mm, as rolled, 99.99+%
Iron, foil, 100x100mm, thickness 0.5mm, hard, 99.5%
Iron, foil, 300x300mm, thickness 0.38mm, hard, 99.5%
Iron, rod, 100mm, diameter 2.0mm, as drawn, 99.95%
Iron, rod, 200mm, diameter 2.0mm, as drawn, 99.99+%
Iron, foil, 100x100mm, thickness 1.5mm, as rolled, 99.5%
Iron, rod, 500mm, diameter 9.5mm, as drawn, soft ingot 99.8+%
Iron, foil, 10mm disks, thickness 0.01mm, 99.85%
Iron, foil, 10mm disks, thickness 0.01mm, 99.99+%
Iron, foil, 10mm disks, thickness 0.020mm, 99.85%