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  • Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.

Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.

Cell cycle (Georgetown, Tex.) (2013-03-09)
Xiaodong Sun, Min Liu, Jihui Hao, Dengwen Li, Youguang Luo, Xiuchao Wang, Yunfan Yang, Fang Li, Wenqing Shui, Quan Chen, Jun Zhou
ABSTRACT

Parkin, an E3 ubiquitin ligase well known for its role in the pathogenesis of juvenile Parkinson disease, has been considered as a candidate tumor suppressor in certain types of cancer. It remains unknown whether parkin is involved in the development of pancreatic cancer, the fourth leading cause of cancer-related deaths worldwide. Herein, we demonstrate the downregulation and copy number loss of the parkin gene in human pancreatic cancer specimens. The expression of parkin negatively correlates with clinicopathological parameters indicating the malignancy of pancreatic cancer. In addition, knockdown of parkin expression promotes the proliferation and tumorigenic properties of pancreatic cancer cells both in vitro and in mice. We further find that parkin deficiency increases the proportion of cells with spindle multipolarity and multinucleation. Parkin-depleted cells also show a significant increase in spindle misorientation. These findings indicate crucial involvement of parkin deficiency in the pathogenesis of pancreatic cancer.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Extract-N-Amp Tissue PCR Kit, sufficient for 100 extractions, sufficient for 100 amplifications
Sigma-Aldrich
Extract-N-Amp Tissue PCR Kit, sufficient for 1000 extractions, sufficient for 1000 amplifications

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