MilliporeSigma

The design and synthesis of inhibitors of pantothenate synthetase.

Organic & biomolecular chemistry (2006-09-23)
Kellie L Tuck, S Adrian Saldanha, Louise M Birch, Alison G Smith, Chris Abell
ABSTRACT

Pantothenate synthetase catalyses the ATP-dependent condensation of D-pantoate and beta-alanine to form pantothenate. Ten analogues of the reaction intermediate pantoyl adenylate, in which the phosphodiester is replaced by either an ester or sulfamoyl group, were designed as potential inhibitors of the enzyme. The esters were all modest competitive inhibitors, the sulfamoyls were more potent, consistent with their closer structural similarity to the pantoyl adenylate intermediate.

MATERIALS
Product Number
Brand
Product Description

Supelco
Diaion® HP-20SS, jar of 100 g
Supelco
Diaion® HP-20SS, bucket of 1000 g