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Nanostructured hybrid of immiscible gold and silicon and its effect on proliferation and adhesion of fibroblasts and osteoblasts.

Journal of biomedical nanotechnology (2014-04-23)
Priyatha Premnath, Bo Tan, Krishnan Venkatakrishnan
ABSTRACT

Hybrid biomaterials are a combination of two or more different materials that work synergistically to produce superior properties. Nano structuring of such hybrid materials has also posed complications. In this study, we present, for the first time a nanofibrous hybrid of gold and silicon fabricated by femtosecond laser synthesis for tissue engineering applications. The formation of a completely new phase, Au3Si (212) is reported. The formation mechanism is explained by vapor condensation. Particle sizes of 2-10 nm and 37-49 nm for gold and gold concentrations of 35-78% are achieved. The effect of this hybrid on cell growth was assessed using fibroblasts and osteoblasts. There was a significant decrease in both osteoblast and fibroblast proliferation with the increase of gold in the hybrid nanostructure. This novel hybrid nanofibrous matrix provides a method to effectively control the proliferation and adhesion of cells. Femtosecond laser synthesis presents a new standard by which not only a single element biomaterial but also multiple immiscible element hybrid biomaterials can be fabricated. This technique provides a paradigm shift in the fabrication of novel nanostructured immiscible hybrid biomaterials.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Gold, foil, thickness 0.1 mm, 99.99% trace metals basis
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Gold, wire, diam. 0.25 mm, 99.99% trace metals basis
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Gold, wire, diam. 1.0 mm, 99.99% trace metals basis
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Gold, wire, diam. 0.5 mm, 99.999% trace metals basis
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Silicon, powder, −60 mesh, 99.998% trace metals basis
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Gold, foil, thickness 0.127 mm, 99.99% trace metals basis
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Silicon, powder, −325 mesh, 99% trace metals basis
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Silicon, pieces, 99.95% trace metals basis
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Gold, powder, <850 μm, ≥99.99% trace metals basis
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Gold, evaporation slug, diam. × L 0.3 cm × 0.6 cm, 99.99% trace metals basis
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Gold, foil, thickness 0.025 mm, 99.99% trace metals basis
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Silicon, wafer, <111>, P-type, contains boron as dopant, diam. × thickness 2 in. × 0.3 mm
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Silicon, wafer (single side polished), <100>, N-type, contains no dopant, diam. × thickness 3 in. × 0.5 mm
Silicon, sphere, 20pcs, diameter 2.0mm, precision sphere grade 25
Silicon, rod, 50mm, diameter 3.15mm, single crystal - random orientation, 100%
Silicon, rod, 80mm, diameter 20mm, single crystal, -100, 99.999%
Silicon, single crystal, -111, n-type, phosphorus doped, diameter 76.2mm, length 0.75mm, 100%
Silicon, rod, 50mm, diameter 5mm, single crystal, -100, 99.999%
Silicon, sheet, 40x40mm, thickness 3.0mm, single crystal, p-type, 100%
Silicon, sphere, 50pcs, diameter 2.0mm, precision sphere grade 25
Gold, rod, 50mm, diameter 2.0mm, as drawn, 99.95%
Silicon, rod, 100mm, diameter 12.7mm, single crystal - random orientation, 100%
Silicon, rod, 50mm, diameter 5.0mm, crystalline, 100%
Silicon, rod, 50mm, diameter 2.0mm, crystalline, 100%
Gold, tube, 10mm, outside diameter 0.15mm, inside diameter 0.05mm, wall thickness 0.05mm, as drawn, 99.95%
Silicon, rod, 100mm, diameter 5.0mm, crystalline, 100%
Gold, tube, 50mm, outside diameter 1.0mm, inside diameter 0.7mm, wall thickness 0.15mm, as drawn, 99.95%
Gold, rod, 10mm, diameter 5.0mm, as drawn, 99.95%
Silicon, rod, 25mm, diameter 3.15mm, single crystal - random orientation, 100%
Silicon, sheet, 10x10mm, thickness 0.5mm, single crystal, -100, 100%