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Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists.

Mini reviews in medicinal chemistry (2004-11-17)
Marlon Cowart, Robert Altenbach, Lawrence Black, Ramin Faghih, Chen Zhao, Arthur A Hancock
ABSTRACT

The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.

MATERIALS
Product Number
Brand
Product Description

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