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The unsolved cyclosporine-induced kidney injury: is paricalcitol a feasible new renoprotective option?

Kidney international (2010-05-29)
Flávio N F Reis
ABSTRACT

The management of cyclosporine A (CsA)-induced nephrotoxicity remains one of the main challenges in kidney transplantation. The animal study by Park et al. proposes that paricalcitol, a vitamin D analog with renoprotective actions reported in other conditions, attenuates CsA-induced kidney injury via the suppression of inflammatory, fibrotic, and apoptotic factors. Before paricalcitol can be considered a feasible new therapeutic option for post-transplantation nephropathy, these interesting data require further studies assessing other mechanisms of CsA-induced nephrotoxicity.

MATERIALS
Product Number
Brand
Product Description

USP
Paricalcitol, United States Pharmacopeia (USP) Reference Standard

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