Piecing together the puzzle of acetaldehyde as a neuroactive agent.

Neuroscience and biobehavioral reviews (2011-08-10)
Mercè Correa, John D Salamone, Kristen N Segovia, Marta Pardo, Rosanna Longoni, Liliana Spina, Alessandra T Peana, Stefania Vinci, Elio Acquas
ABSTRACT

Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen a revitalized and uninterrupted interest. Acetaldehyde, per se, and as a product of ethanol metabolism, is responsible for many pharmacological effects which are not clearly distinguishable from those of its parent compound, ethanol. Consequently, the most recent advances in acetaldehyde's psychopharmacology have been inspired by the experimental approach to test the hypothesis that some of the effects of ethanol are mediated by acetaldehyde and, in this regard, the characterization of metabolic pathways for ethanol and the localization within discrete brain regions of these effects have revitalized the interest on the role of acetaldehyde in ethanol's central effects. Here we present and discuss a wealth of experimental evidence that converges to suggest that acetaldehyde is an intrinsically active compound, is metabolically generated in the brain and, finally, mediates many of the psychopharmacological properties of ethanol.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Acetaldehyde, ACS reagent, ≥99.5%
Supelco
Acetaldehyde, puriss. p.a., anhydrous, ≥99.5% (GC)
Supelco
Acetaldehyde, ReagentPlus®, ≥99.0% (GC)
Sigma-Aldrich
Acetaldehyde, natural, FG
Supelco
Acetaldehyde, PESTANAL®, analytical standard
Sigma-Aldrich
Acetaldehyde solution, 40 wt. % in H2O
Sigma-Aldrich
Acetaldehyde solution, natural, 50 wt. % ethanol, FG
Sigma-Aldrich
Acetaldehyde solution, 50 wt. % in ethanol
Sigma-Aldrich
Acetaldehyde solution, 5 M in THF
Sigma-Aldrich
Acetaldehyde, ≥99%, meets FCC analytical specification
Sigma-Aldrich
Acetaldehyde solution, 40 wt. % in isopropanol