Using lithium as a neuroprotective agent in patients with cancer.

BMC medicine (2012-11-06)
Mustafa Khasraw, David Ashley, Greg Wheeler, Michael Berk
ABSTRACT

Neurocognitive impairment is being increasingly recognized as an important issue in patients with cancer who develop cognitive difficulties either as part of direct or indirect involvement of the nervous system or as a consequence of either chemotherapy-related or radiotherapy-related complications. Brain radiotherapy in particular can lead to significant cognitive defects. Neurocognitive decline adversely affects quality of life, meaningful employment, and even simple daily activities. Neuroprotection may be a viable and realistic goal in preventing neurocognitive sequelae in these patients, especially in the setting of cranial irradiation. Lithium is an agent that has been in use for psychiatric disorders for decades, but recently there has been emerging evidence that it can have a neuroprotective effect.This review discusses neurocognitive impairment in patients with cancer and the potential for investigating the use of lithium as a neuroprotectant in such patients.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Lithium, granular, 99% trace metals basis
Sigma-Aldrich
Lithium, ribbon, thickness × W 0.38 mm × 23 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, ribbon, thickness × W 0.75 mm × 19 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, granular, 4-10 mesh particle size, high sodium, 99% (metals basis)
Lithium, foil, 25x100mm, thickness 0.6mm, as rolled, 99.9%
Sigma-Aldrich
Lithium, ribbon, thickness × W 0.75 mm × 45 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, rod, diam. 12.7 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, wire, diam. 3.2 mm, in mineral oil, ≥98%
Sigma-Aldrich
Lithium, wire (in mineral oil), diam. 3.2 mm, 99.9% trace metals basis
Sigma-Aldrich
Lithium, foil, not light tested, 38x500mm, thickness 0.20mm, as rolled, 99.9%
Sigma-Aldrich
Lithium, ribbon, thickness × W 1.5 mm × 100 mm, 99.9% trace metals basis
Lithium, foil, not light tested, 38x200mm, thickness 0.20mm, as rolled, 99.9%