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  • The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides.

The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides.

Cold Spring Harbor perspectives in medicine (2012-10-23)
Marisa Roberto, Nicholas W Gilpin, George R Siggins
ABSTRACT

Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug seeking and drug taking, loss of control in limiting intake, and the emergence of a withdrawal syndrome in the absence of the drug. Accumulating evidence suggests an important role for synaptic transmission in the central amygdala (CeA) in mediating alcohol-related behaviors and neuroadaptative mechanisms associated with alcohol dependence. Acute alcohol facilitates γ-aminobutyric acid-ergic (GABAergic) transmission in CeA via both pre- and postsynaptic mechanisms, and chronic alcohol increases baseline GABAergic transmission. Acute alcohol inhibits glutamatergic transmission via effects at N-methyl-d-aspartate (NMDA) and AMPA receptors in CeA, whereas chronic alcohol up-regulates N-methyl-d-aspartate receptor (NMDAR)-mediated transmission. Pro- (e.g., corticotropin-releasing factor [CRF]) and anti-stress (e.g., NPY, nociceptin) neuropeptides affect alcohol- and anxiety-related behaviors, and also alter the alcohol-induced effects on CeA neurotransmission. Alcohol dependence produces plasticity in these neuropeptide systems, reflecting a recruitment of those systems during the transition to alcohol dependence.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
γ-Aminobutyric acid, ≥99%
Sigma-Aldrich
γ-Aminobutyric acid, BioXtra, ≥99%
Vigabatrin impurity D, European Pharmacopoeia (EP) Reference Standard
Supelco
γ-Aminobutyric acid, analytical standard