MilliporeSigma

Zinc in traumatic brain injury: from neuroprotection to neurotoxicity.

Current opinion in clinical nutrition and metabolic care (2013-08-16)
Deborah R Morris, Cathy W Levenson
ABSTRACT

In light of the recent recognition that even mild forms of traumatic brain injury (TBI) can lead to long-term cognitive and behavioral deficits, this review examines recent data on the neuroprotective and neurotoxic roles of zinc after brain injury. Data show that treatment using dietary and parenteral zinc supplementation can reduce TBI-associated depression and improve cognitive function, specifically spatial learning and memory. However, excessive release of free zinc, particularly in the hippocampus associated with acute injury, can lead to increases in protein ubiquitination and neuronal death. This work shows the need for future research to clarify the potentially contradictory roles of zinc in the hippocampus and define the clinical use of zinc as a treatment following brain injury in humans. This is particularly important given the finding that zinc may reduce TBI-associated depression, a common and difficult outcome to treat in all forms of TBI.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Zinc, foil, thickness 0.25 mm, 99.9% trace metals basis
Sigma-Aldrich
Zinc, wire, diam. 1.0 mm, 99.995% trace metals basis
Sigma-Aldrich
Zinc, powder, <150 μm, 99.995% trace metals basis
Sigma-Aldrich
Zinc, purum, powder
Sigma-Aldrich
Zinc, granular, 30-100 mesh, 99%
Sigma-Aldrich
Zinc, mossy, ≥99%
Zinc, foil, 0.5m coil, thickness 0.025mm, as rolled, 99.95+%
Zinc, foil, 0.5m coil, thickness 0.25mm, as rolled, 99.95+%
Zinc, foil, 25x25mm, thickness 0.175mm, as rolled, 99.95+%
Zinc, foil, 50x50mm, thickness 3mm, as rolled, 99.99+%
Zinc, foil, 0.5m coil, thickness 0.35mm, as rolled, 99.95+%
Zinc, foil, 50x50mm, thickness 0.25mm, as rolled, 99.95+%
Zinc, foil, 15mm disks, thickness 0.175mm, as rolled, 99.95+%
Zinc, foil, 0.3m coil, thickness 0.075mm, as rolled, 99.95+%
Zinc, foil, 25x25mm, thickness 0.5mm, as rolled, 99.99+%
Zinc, foil, 50x50mm, thickness 0.175mm, as rolled, 99.95+%
Zinc, foil, 50x50mm, thickness 6mm, as rolled, polished on both sides, 99.99+%
Zinc, foil, 10mm disks, thickness 0.20mm, as rolled, 99.95+%
Zinc, foil, 0.5m coil, thickness 1.0mm, as rolled, 99.95+%
Zinc, foil, 50x50mm, thickness 0.35mm, as rolled, 99.95+%
Zinc, foil, 15mm disks, thickness 0.01mm, 99.9%
Zinc, foil, 15mm disks, thickness 0.20mm, as rolled, 99.95+%
Zinc, foil, 300x300mm, thickness 0.1mm, as rolled, 99.95+%
Zinc, foil, 10mm disks, thickness 0.5mm, as rolled, 99.95+%
Zinc, foil, 10mm disks, thickness 0.05mm, as rolled, 99.99+%
Zinc, foil, 10mm disks, thickness 0.05mm, as rolled, 99.95+%
Zinc, foil, 500x500mm, thickness 1.0mm, as rolled, 99.7%
Zinc, foil, 15mm disks, thickness 0.02mm, 99.9%
Zinc, foil, 10mm disks, thickness 0.175mm, as rolled, 99.95+%
Zinc, foil, 15mm disks, thickness 0.025mm, as rolled, 99.99+%