MilliporeSigma

Iron homeostasis in breast cancer.

Cancer letters (2014-02-04)
Oriana Marques, Berta Martins da Silva, Graça Porto, Carlos Lopes
ABSTRACT

Iron is an essential element and a critical component of molecules involved in energy production, cell cycle and intermediate metabolism. However, the same characteristic chemistry that makes it so biologically versatile may lead to iron-associated toxicity as a consequence of increased oxidative stress. The fact that free iron accumulates with age and generates ROS led to the hypothesis that it could be involved in the etiogenesis of several chronic diseases. Iron has been consistently linked to carcinogenesis, either through persistent failure in the redox balance or due to its critical role in cellular proliferation. Several reports have given evidence that alterations in the import, export and storage of cellular iron may contribute to breast cancer development, behavior and recurrence. In this review, we summarize the basic mechanisms of systemic and cellular iron regulation and highlight the findings that link their deregulation with breast cancer. To conclude, progresses in iron chelation therapy in breast cancer, as a tool to fight chemotherapy resistance, are also reviewed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Iron, wire, diam. 0.5 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Iron, chips, 99.98% trace metals basis
Sigma-Aldrich
Iron, foil, thickness 0.1 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Iron, rod, diam. 6.3 mm, 99.98% trace metals basis
Sigma-Aldrich
Iron, powder, −325 mesh, 97%
Sigma-Aldrich
Iron, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)
Iron, IRMM®, certified reference material, 0.5 mm wire
Iron, foil, not light tested, 50x50mm, thickness 0.0005mm, temporary acrylic support, 99.85%
Iron, foil, light tested, 25x25mm, thickness 0.015mm, 99.85%
Iron, foil, not light tested, 100x100mm, thickness 0.006mm, 99.85%
Iron, foil, not light tested, 150x150mm, thickness 0.008mm, 99.85%
Iron, foil, not light tested, 50x50mm, thickness 0.001mm, 99.85%
Iron, wire reel, 0.5m, diameter 0.25mm, hard, 99.99+%
Iron, rod, 50mm, diameter 5.0mm, as drawn, 99.99+%
Iron, foil, not light tested, 25x25mm, thickness 0.002mm, 99.85%
Iron, rod, 100mm, diameter 8.0mm, as drawn, 99.99+%
Iron, foil, 25x25mm, thickness 0.25mm, hard, 99.5%
Iron, foil, 150x150mm, thickness 2.0mm, as rolled, armco« soft ingot 99.8%
Iron, rod, 1000mm, diameter 12.7mm, as drawn, 98+%
Iron, foil, not light tested, 25x25mm, thickness 0.009mm, 99.85%
Iron, rod, 50mm, diameter 100mm, as drawn, armcO« soft ingot 99.8%
Iron, rod, 200mm, diameter 9.5mm, as drawn, 98+%
Iron, foil, 25x25mm, thickness 1.83mm, Quarter hard, 99.5%
Iron, foil, 100x100mm, thickness 2.0mm, as rolled, armco« soft ingot 99.8%
Iron, rod, 500mm, diameter 25mm, as drawn, 98+%
Iron, tube, 1000mm, outside diameter 12.0mm, inside diameter 10mm, wall thickness 1.0mm, annealed, 99.5%
Iron, microfoil, disks, 10mm, thinness 0.05μm, specific density 40.44μg/cm2, permanent mylar 3.5μm support, 99.99+%
Iron, foil, not light tested, 50x50mm, thickness 0.00075mm, temporary acrylic support, 99.85%
Iron, rod, 300mm, diameter 5.0mm, as drawn, 99.99+%
Iron, foil, not light tested, 150x150mm, thickness 0.009mm, 99.85%