MilliporeSigma

Iron: effect of overload and deficiency.

Metal ions in life sciences (2014-01-29)
Robert C Hider, Xiaole Kong
ABSTRACT

Iron is a redox active metal which is abundant in the Earth's crust. It has played a key role in the evolution of living systems and as such is an essential element in a wide range of biological phenomena, being critical for the function of an enormous array of enzymes, energy transduction mechanisms, and oxygen carriers. The redox nature of iron renders the metal toxic in excess and consequently all biological organisms carefully control iron levels. In this overview the mechanisms adopted by man to control body iron levels are described.Low body iron levels are related to anemia which can be treated by various forms of iron fortification and supplementation. Elevated iron levels can occur systemically or locally, each giving rise to specific symptoms. Systemic iron overload results from either the hyperabsorption of iron or regular blood transfusion and can be treated by the use of a selection of iron chelating molecules. The symptoms of many forms of neurodegeneration are associated with elevated levels of iron in certain regions of the brain and iron chelation therapy is beginning to find an application in the treatment of such diseases. Iron chelators have also been widely investigated for the treatment of cancer, tuberculosis, and malaria. In these latter studies, selective removal of iron from key enzymes or iron binding proteins is sought. Sufficient selectivity between the invading organism and the host has yet to be established for such chelators to find application in the clinic.Iron chelation for systemic iron overload and iron supplementation therapy for the treatment of various forms of anemia are now established procedures in clinical medicine. Chelation therapy may find an important role in the treatment of various neurodegenerative diseases in the near future.

MATERIALS
Product Number
Brand
Product Description

Iron, foil, 100x100mm, thickness 1.0mm, as rolled, 99.5%
Iron, rod, 500mm, diameter 19.0mm, as drawn, 98+%
Iron, rod, 200mm, diameter 3.0mm, as drawn, 99.99+%
Iron, rod, 200mm, diameter 30mm, as drawn, armcO« soft ingot 99.8%
Iron, foil, 25x25mm, thickness 0.15mm, hard, 99.5%
Iron, rod, 500mm, diameter 4.8mm, as drawn, 98+%
Iron, rod, 200mm, diameter 100mm, as drawn, armcO« soft ingot 99.8%
Iron, foil, 25x25mm, thickness 1.0mm, as rolled, 99.99+%
Iron, foil, 150x150mm, thickness 1.0mm, as rolled, 99.5%
Iron, foil, 100x100mm, thickness 0.38mm, hard, 99.5%
Iron, rod, 100mm, diameter 6.0mm, as drawn, 99.99+%
Iron, foil, 25x25mm, thickness 0.1mm, hard, 99.5%
Iron, foil, 100x100mm, thickness 3.1mm, as rolled, 99.95%
Iron, rod, 50mm, diameter 6.0mm, as drawn, 99.99+%
Iron, rod, 500mm, diameter 3.0mm, as drawn, 99.99+%
Iron, tube, 100mm, outside diameter 12.0mm, inside diameter 9mm, wall thickness 1.5mm, annealed, 99.5%
Iron, wire reel, 1m, diameter 0.5mm, hard, 99.99+%
Iron, tube, 500mm, outside diameter 20.0mm, inside diameter 16mm, wall thickness 2.0mm, annealed, 99.5%
Iron, tube, 100mm, outside diameter 15.0mm, inside diameter 12mm, wall thickness 1.5mm, annealed, 99.5%
Iron, foil, 150x150mm, thickness 1.0mm, as rolled, armco« soft ingot 99.8%
Iron, foil, 100x100mm, thickness 0.5mm, as rolled, 99.99+%
Iron, foil, 300x300mm, thickness 0.5mm, hard, 99.5%
Iron, wire reel, 20m, diameter 0.5mm, as drawn, 99.95%
Iron, foil, 10mm disks, thickness 0.015mm, 99.99+%
Iron, foil, not light tested, 50x50mm, thickness 0.004mm, 99.85%
Iron, foil, 8mm disks, thickness 0.038mm, hard, 99.5%
Iron, foil, not light tested, 50x50mm, thickness 0.004mm, 99.99+%
Iron, foil, 6mm disks, thickness 0.005mm, 99.85%
Iron, foil, 8mm disks, thickness 0.015mm, 99.99+%
Iron, foil, 6mm disks, thickness 0.025mm, hard, 99.5%