[Toxicity and metabolism of acrylonitrile].

Medycyna pracy (1981-01-01)
A Sapota, J Chmielnicka
ABSTRACT

The paper presents the problem of occupational exposure to acrylonitrile vapours and toxic properties of this compound, as well as its metabolism in experimental animals, including its administration route. In addition, it deals with the mechanism of its toxic effects depending on the reactivity of the functional group of acrylonitrile particle. The authors discuss also the latest views on the capacity of acrylonitrile metabolites [S-(2-cyanoethyl)-mercapturic acid and rhodanates], depending on the route of acrylonitrile administration to rats.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Acrylonitrile, ≥99%, contains 35-45 ppm monomethyl ether hydroquinone as inhibitor
Sigma-Aldrich
Acrylonitrile, ≥99%, contains 35-45 ppm monomethyl ether hydroquinone as inhibitor
Supelco
Acrylonitrile, analytical standard
Supelco
Acrylonitrile solution, certified reference material, 5000 μg/mL in methanol