Polyacrylamide-based glycoconjugates as tools in glycobiology.

Glycoconjugate journal (1999-01-09)
N V Bovin
ABSTRACT

This review describes the synthesis, physicochemical characteristics and application for studying carbohydrate-binding proteins of polyacrylamide (PAA) type neoglycoconjugates. An approach to the synthesis of conjugates based on the interaction of activated polyacrylic acid with omega-aminoalkyl glycosides has been developed. Both the molecules of Glyc-PAA and the conjugates bearing various labels and effectors, as well as sorbents, and glycosurfaces can be designed using this method. Examples of the application of the conjugates as tools for the study of lectins, antibodies, and glycosyltransferases in glycobiology, cytochemistry and histochemistry are described along with the prospects of the further development of the presented approach in glycotechnology and medicine.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Polyacrylamide, nonionic water-soluble polymer
Sigma-Aldrich
Polyacrylamide, average Mn 150,000
Sigma-Aldrich
Polyacrylamide, average Mn 40,000